A Novel Framework for Teasing Out Mechanisms of DILI

In this webinar presented by InSphero, Liver Toxicology Team Leader Dr. Monika Kijanska will introduce a framework for mechanistic toxicology investigations, based on a suite of causality assays developed for our 3D InSight™ Liver Toxicology Platform. Monika will discuss how to design experimental programs that help validate relationships between events that trigger toxic responses and identify adverse outcome pathways implicated in drug-induced liver injury, and present example data generated using our liver toxicology platform. You will learn:

• How one simple, proven causality assay applied using different models at different time points can help tease out mechanisms of DILI
• How to tune and adapt 3D-optimized causality assays for a wide range of pathways using specific pathway modulators for DILI-specific mechanistic investigations and mechanism based screening
• Advantages of using a scalable, robust, and versatile 3D in vitro platform for liver toxicology studies.

Presented by a partner of the recently established EU-ToxRisk Commercial Platform for New Approach Methods (NAMs) in Safety Assessment.