SaferWorldbyDesign Webinars

A Novel Framework for Teasing Out Mechanisms of DILI

Tuesday, 23 June 2020 - 16:00 CET

In this webinar presented by InSphero, Liver Toxicology Team Leader Dr. Monika Kijanska will introduce a framework for mechanistic toxicology investigations, based on a suite of causality assays developed for our 3D InSightâ„¢ Liver Toxicology Platform. Monika will discuss how to design experimental programs that help validate relationships between events that trigger toxic responses and identify adverse outcome pathways implicated in drug-induced liver injury, and present example data generated using our liver toxicology platform. You will learn:

  • How one simple, proven causality assay applied using different models at different time points can help tease out mechanisms of DILI
  • How to tune and adapt 3D-optimized causality assays for a wide range of pathways using specific pathway modulators for DILI-specific mechanistic investigations and mechanism based screening
  • Advantages of using a scalable, robust, and versatile 3D in vitro platform for liver toxicology studies.

Presented by a partner of the recently established EU-ToxRisk Commercial Platform for New Approach Methods (NAMs) in Safety Assessment.

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Edelweiss Connect GmbH is registered as a limited company with Handelsregisteramt of Kanton Basel-Stadt Swiss ID (UID) number: CHE-114.414.615
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