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GARDskin Dose-Response

Product category: In vitro assays
Product code: GARDskin Dose-Response

GARDĀ®skin Dose-Response

In vitro skin sensitizing quantitative potency assessment

GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin (OECD TG 442E). GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.

Additionally, readouts provide a prediction of correlating LLNA EC3 values, which are traditionally used to measure the skin sensitizing potency of chemicals. Furthermore, the readout can also predict human skin sensitizing potency and/or GHS/CLP classification (1A or 1B), all with high statistical significance.

How it works:

The GARDskin Dose-Response investigates the GARDskin response values in a titrated range of multiple concentrations in a dose-response manner to find the concentration threshold required to induce a positive Decision Value. This threshold concentration, cDV0, is used to estimate the inherent sensitizing potency of a chemical. A low value indicates a high inherent skin sensitizing potency and a high value indicates a low inherent skin sensitizing potency. The cDV0 can also be extrapolated to a traditional EC3 value from Local Lymph Node Assay, human skin sensitizing potency, and/or GHS/CLP classification 1A or1B depending on the need.

Contact us for a quotation.

Vendor: SenzaGen


Assay

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Edelweiss Connect GmbH is registered as a limited company with Handelsregisteramt of Kanton Basel-Stadt Swiss ID (UID) number: CHE-114.414.615
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