GARDskin Dose-Response

Product category: In vitro assays
Product code: GARDskin Dose-Response

GARD®skin Dose-Response

In vitro skin sensitizing quantitative potency assessment

GARDskin Dose-Response is an in vitro test for quantitative skin sensitizing potency assessment of chemicals, adapted from GARDskin (OECD TG 442E). GARDskin Dose-Response provides an estimated threshold concentration for a test substance to induce skin sensitizing effects; a lower concentration equals a higher potency and vice versa. This threshold concentration can be used for skin sensitizing potency ranking of candidate ingredients and early decision-making during product development.

Additionally, readouts provide a prediction of correlating LLNA EC3 values, which are traditionally used to measure the skin sensitizing potency of chemicals. Furthermore, the readout can also predict human skin sensitizing potency and/or GHS/CLP classification (1A or 1B), all with high statistical significance.

How it works:

The GARDskin Dose-Response investigates the GARDskin response values in a titrated range of multiple concentrations in a dose-response manner to find the concentration threshold required to induce a positive Decision Value. This threshold concentration, cDV0, is used to estimate the inherent sensitizing potency of a chemical. A low value indicates a high inherent skin sensitizing potency and a high value indicates a low inherent skin sensitizing potency. The cDV0 can also be extrapolated to a traditional EC3 value from Local Lymph Node Assay, human skin sensitizing potency, and/or GHS/CLP classification 1A or1B depending on the need.

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Vendor: SenzaGen



SaferWorldbyDesign integrates in silico and in vitro methods to develop standard and premium Integrated Approaches to Testing and Assessment (IATAs), including methods that support ingredient and formulation screening and testing, product design and the preparation of Regulatory Dossiers.


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